Correlations of Hormone Receptors (ER and PR), Her2/neu and p53 Expression in Breast Ductal Carcinoma Among Yemeni Women



Hussain Gadelkarim Ahmed1, *, Mohammed Ali Al-Adhraei2, Abdullah Kasim Al-Thobhani3
1 Department of Histopathology and Cytology, Yemen. Faculty of Medical laboratory Sciences, University of Khartoum; Sudanese Cancer Foundation, Khartoum, Sudan
2 National Oncology Center, Al-Jumhory Teaching Hospital, Sana'a, Yemen
3 Department of pathology, Faculty of Medicine, Sana’a University,Yemen


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© 2011 Ahmed et al.;

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the University of Khartoum, 102, Faculty of Medical Laboratory Sciences, Khartoum, Sudan; Tel: +249912698998; Fax: +249155130423; E-mails: Hussain@uofk.edu, hussaingad1972@yahoo.com.


Abstract

Aims: The purpose of this study was to determine if any relationship exists between Estrogen Receptor (ER),Progesterone Receptor (PR), Her2/neu, P53, and clinicopathological factors in female breast ductal carcinoma. Materials and Methods: One hundred and thirty seven (IDC=124, NIDC=13) ductal carcinomas were clinicopathologically and immunohistochemically analyzed and compared with 20 control cases of benign breast lesions in which assessment of Her-2/neu, ER, PR, and P53 has been performed, prospectively. Chi-square analysis was then used to correlate the above observations. Results: The overall immunoexpression of ER, PR, Her2/neu and P53 were 43.8%, 27%, 30.6% and 48.9%, respectively, of the 137 ductal carcinomas. A significant Positive association between ER or PR expression with lymph node involvement was found ( p= 0.004, p= 0.022 respectively), while p53 was found to be negatively associated with lymph nodes involvement (p= 0.03, 0.02, respectively). P53 also associated negatively to lymph node status (P=0.03) and positively with borderline tumor grade (p= 0.03). Conclusion: There are high rates of positive expression of ER, PR, Her2/neu and P53 among Yamani women with breast ductal carcinoma.

Keywords: ER, PR, Her2/neu and p53, Breast Carcinoma, Yemeni.