RESEARCH ARTICLE


NK-KIR Gene Repertoire and Outcome of Patients with Acute Myeloid Leukemia after Allogeneic Hematopoietic Cell Transplantation from Unrelated Donors



Wilasinee Chainonthee1, *, Martin Bornhäuser1, Monika Füssel2, Gerhard Ehninger1, Ralf Wassmuth1, 2
1 Medizinische Klinik u. Poliklinik I, Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden,Dresden, Germany
2 DKMS Life Science Lab GmbH, Germany


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© 2013 Chainonthee et al.;

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Medizinische Klinik u. Poliklinik I, Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden, Fetscherstr. 74 • 01307 Dresden, Germany; Tel: + 49 351 458 4706; Fax: + 49 351 458 5362; E-mail: Wilasinee.Chainonthee@uniklinikum-dresden.de


Abstract

In this retrospective study, the influence of donor and recipient KIR-gene content and their respective ligands including clinical parameters as potential confounding variables on the outcome of 150 acute myeloid leukemia (AML) patients undergoing allogenic hematopoietic cell transplantation (HCT) from unrelated donors was systematically investigated. There was no significant influence of KIR ligand mismatching and of donor/recipient KIR haplotype combinations on overall survival (OS), disease free survival (DSF), non-relapse mortality (NRM) and relapse. Isolated effects of KIR haplotypes, were detected for acute, chronic Graft versus Host Disease (aGvHD and cGvHD) as well as for the cumulative incidence of non-relapse mortality and relapse. The incidence of non-relapse mortality was evaluated in donor and recipient pairs harbouring KIR AA homozygosity (AA/Bx: p=0.038, HR=0.73, 95% CI=0.35-1.46 and AA/AA: p=0.043, HR=0.64, 95% CI 0.53-1-17). Our data suggest that KIR genotyping may be useful in patients in whom several HLAidentical unrelated donors can be identified but is probably not necessary for the primary donor selection algorithm.

Keywords: KIR, Stem Sell Transplantation, GvL.